Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects
Figure 5
The effect of 1-week cephalothin (CLT) on the intracolonic (colo) TNBS-sensitized visceromotor response to graded colorectal distension was compared in female mice. In animals treated with 1-week vehicle and then intracolonic TNBS (100 μl, 7 mg/ml) (●), administered 1 week before the study, significant increased visceromotor response to colorectal distension (*) was observed, compared to 1-week vehicle and intracolonic vehicle (○). One-week CLT treatment did not attenuate the enhanced visceromotor response to colorectal distension caused by intracolonic TNBS (▲). per group. * compared to 1-week vehicle + intracolonic vehicle group.
