507029.fig.005
Figure 5: The effect of 1-week cephalothin (CLT) on the intracolonic (colo) TNBS-sensitized visceromotor response to graded colorectal distension was compared in female mice. In animals treated with 1-week vehicle and then intracolonic TNBS (100 μl, 7 mg/ml) (●), administered 1 week before the study, significant increased visceromotor response to colorectal distension (* 𝑃 < 0 . 0 5 ) was observed, compared to 1-week vehicle and intracolonic vehicle (○). One-week CLT treatment did not attenuate the enhanced visceromotor response to colorectal distension caused by intracolonic TNBS (▲). 𝑛 = 6 - 7 per group. * 𝑃 < 0 . 0 1 compared to 1-week vehicle + intracolonic vehicle group.