507029.fig.006
Figure 6: The effect of GLT-1 overexpression on the dextran-sodium-sulfate- (DSS-) sensitized visceromotor response to graded colorectal distension was compared in female mice. In animals treated with oral 4% DSS for 1 week followed by 1-week daily vehicle injections (ip) (●), significant increased (36–60%) visceromotor response to colorectal distension (* 𝑃 < 0 . 0 5 ) was observed, compared to 1-week vehicle and intracolonic vehicle (○). One-week CTX treatment abolishes the enhanced visceromotor response to colorectal distension caused by oral 4% DSS for 1 week (▲). 𝑛 = 7–9 per group. * 𝑃 < 0 . 0 1 compared to 1-week vehicle + intracolonic vehicle group.