Figure 6: The effect of GLT-1 overexpression on the dextran-sodium-sulfate- (DSS-) sensitized visceromotor response to graded colorectal distension was compared in female mice. In animals treated with oral 4% DSS for 1 week followed by 1-week daily vehicle injections (ip) (●), significant increased (36–60%) visceromotor response to colorectal distension (*) was observed, compared to 1-week vehicle and intracolonic vehicle (○). One-week CTX treatment abolishes the enhanced visceromotor response to colorectal distension caused by oral 4% DSS for 1 week (▲). = 7–9 per group. * compared to 1-week vehicle + intracolonic vehicle group.