- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Pain Research and Treatment
Volume 2011 (2011), Article ID 507029, 10 pages
Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects
1Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH 43210, USA
2Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
3The Research Institute at Nationwide Children's Hospital, Columbus, OH 43210, USA
4Department of Oral Biology, The Ohio State University, Columbus, OH 43210, USA
Received 16 July 2011; Accepted 12 September 2011
Academic Editor: Anna Maria Aloisi
Copyright © 2011 Y. Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. N. Sengupta, “Visceral pain: the neurophysiological mechanism,” Handbook of Experimental Pharmacology, vol. 194, pp. 31–74, 2009.
- D. R. Robinson and G. F. Gebhart, “Inside information: the unique features of visceral sensation,” Molecular Interventions, vol. 8, no. 5, pp. 242–253, 2008.
- A. D. Farmer and Q. Aziz, “Recent advances in chronic visceral pain,” Current Opinion in Supportive and Palliative Care, vol. 2, no. 2, pp. 116–121, 2008.
- Y. Hu, W. Li, L. Lu et al., “An anti-nociceptive role for ceftriaxone in chronic neuropathic pain in rats,” Pain, vol. 148, no. 2, pp. 284–301, 2010.
- S. Maeda, A. Kawamoto, Y. Yatani, H. Shirakawa, T. Nakagawa, and S. Kaneko, “Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats,” Molecular Pain, vol. 4, p. 65, 2008.
- M. Yang, K. Roman, D.-F. Chen, Z.-G. Wang, and R. L. Stephens Jr., “GLT-1 over-expression attenuates bladder nociception, and cross-organ sensitization of bladder nociception and function,” American Journal of Physiology—Renal Physiology, vol. 300, no. 6, pp. F1353–F1359, 2011.
- B. R. Miller, J. L. Dorner, M. Shou et al., “Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse,” Neuroscience, vol. 153, no. 1, pp. 329–337, 2008.
- J. D. Rothstein, S. Patel, M. R. Regan et al., “β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression,” Nature, vol. 433, no. 7021, pp. 73–77, 2005.
- K. Vloet, “Gene therapy for chronic pain enters first human trial,” Online Source, 2008, http://www2.med.umich.edu/prmc/media/newsroom/details.cfm?ID=638.
- Y. Sari, A. L. Prieto, S. J. Barton, B. R. Miller, and G. V. Rebec, “Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington's disease,” Journal of Biomedical Science, vol. 17, no. 1, p. 62, 2010.
- K. D. Foust, E. Nurre, C. L. Montgomery, A. Hernandez, C. M. Chan, and B. K. Kaspar, “Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes,” Nature Biotechnology, vol. 27, no. 1, pp. 59–65, 2009.
- Y. Lin, G. Tian, K. Roman et al., “Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 296, no. 1, pp. G129–G134, 2009.
- J. L. K. Hylden and G. L. Wilcox, “Intrathecal morphine in mice: a new technique,” European Journal of Pharmacology, vol. 67, no. 2-3, pp. 313–316, 1980.
- Y. Yan, V. Kolachala, G. Dalmasso et al., “Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis,” PLoS ONE, vol. 4, no. 6, Article ID e6073, 2009.
- W. J. Liaw, R. L. Stephens Jr., B. C. Binns et al., “Spinal glutamate uptake is critical for maintaining normal sensory transmission in rat spinal cord,” Pain, vol. 115, no. 1-2, pp. 60–70, 2005.
- S. V. Coutinho, M. O. Urban, and G. F. Gebhart, “The role of CNS NMDA receptors and nitric oxide in visceral hyperalgesia,” European Journal of Pharmacology, vol. 429, no. 1–3, pp. 319–325, 2001.
- Q. Zhou, D. D. Price, R. M. Caudle, and G. N. Verne, “Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis,” Pain, vol. 134, no. 1-2, pp. 9–15, 2008.
- J. Li, J. A. McRoberts, H. S. Ennes et al., “Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 291, no. 2, pp. G219–G228, 2006.
- H. Allgayer, “Clinical relevance of oxygen radicals in inflammatory bowel disease—facts and fashion,” Klinische Wochenschrift, vol. 69, no. 21–23, pp. 1001–1003, 1991.
- N. Eijkelkamp, A. Kavelaars, S. Elsenbruch, M. Schedlowski, G. Holtmann, and C. J. Heijnen, “Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 293, no. 4, pp. G749–G757, 2007.
- E. F. Verdú, P. Bercik, M. Verma-Gandhu et al., “Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice,” Gut, vol. 55, no. 2, pp. 182–190, 2006.
- R. R. Ji, R. W. Gereau, M. Malcangio, and G. R. Strichartz, “MAP kinase and pain,” Brain Research Reviews, vol. 60, no. 1, pp. 135–148, 2009.
- M. E. Hester, K. D. Foust, R. W. Kaspar, and B. K. Kaspar, “AAV as a gene transfer vector for the treatment of neurological disorders: novel treatment thoughts for ALS,” Current Gene Therapy, vol. 9, no. 5, pp. 428–433, 2009.
- A. A. te Velde, M. I. Verstege, and D. W. Hommes, “Critical appraisal of the current practice in murine TNBS-induced colitis,” Inflammatory Bowel Diseases, vol. 12, no. 10, pp. 995–999, 2006.
- E. M. M. Quigley, “Therapies aimed at the gut microbiota and inflammation: antibiotics, prebiotics, probiotics, synbiotics, anti-inflammatory therapies,” Gastroenterology Clinics of North America, vol. 40, no. 1, pp. 207–222, 2011.
- J. I. Choi, C. I. Svensson, F. J. Koehrn, A. Bhuskute, and L. S. Sorkin, “Peripheral inflammation induces tumor necrosis factor dependent AMPA receptor trafficking and Akt phosphorylation in spinal cord in addition to pain behavior,” Pain, vol. 149, no. 2, pp. 243–253, 2010.
- Y. X. Tao, “Dorsal horn α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking in inflammatory pain,” Anesthesiology, vol. 112, no. 5, pp. 1259–1265, 2010.