Table 3: Colonic myeloperoxidase (MPO) issue levels after oral 4% DSS; effect of therapeutic ceftriaxone.

Treatment ( 𝑛 )Mean ± SEM (units/mg)

1 wk veh + oral H2O [4] 0 . 2 1 ± 0 . 0 1
1 wk CTX + oral H2O [11] 0 . 1 7 ± 0 . 0 3
1 wk veh + 4% DSS [4] 0 . 5 0 ± 0 . 0 6 a
1 wk CTX + 4% DSS [4] 0 . 3 5 ± 0 . 0 5 a

Ceftriaxone (200 mg/kg daily for 1 week), administered one week after initiation of colonic inflammation by oral 4% DSS in the drinking water, was ineffective to significantly reduce colonic inflammation, measured by MPO activity at day 14. a 𝑃 < 0 . 0 0 5 compared to 1-week veh + oral H2O.