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Pain Research and Treatment
Volume 2011 (2011), Article ID 650320, 9 pages
Clinical Study

Sedation and Analgesia in Intensive Care: A Comparison of Fentanyl and Remifentanil

1Medical Department, Abbott Pharmaceuticals, Meral Plaza, Umraniye, Istanbul, Turkey
2ICU Department, Ministry of Health Teaching and Research Hospital, Göztepe, Istanbul, Turkey
3Yeditepe University School of Pharmacy, 26 August Campus, 34755 Atasehir, Istanbul, Turkey

Received 2 September 2010; Revised 18 April 2011; Accepted 1 May 2011

Academic Editor: Steve McGaraughty

Copyright © 2011 F. Cevik et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. G. Costa, P. Chiarandini, and G. D. Rocca, “Sedation in the critically Ill patient,” Transplantation Proceedings, vol. 38, no. 3, pp. 803–804, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. J. Jacobi, G. L. Fraser, D. B. Coursin et al., “Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult,” Critical Care Medicine, vol. 30, no. 1, pp. 119–141, 2002. View at Scopus
  3. B. Muellejans, A. López, M. H. Cross, C. Bonome, L. Morrison, and A. J. Kirkham, “Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial,” Critical Care, vol. 8, no. 1, pp. R1–R11, 2004. View at Scopus
  4. G. Park, D. Coursin, E. W. Ely et al., “Balancing sedation and analgesia in the critically ill,” Critical Care Clinics, vol. 17, no. 4, pp. 1015–1027, 2001. View at Scopus
  5. What is Clinical Pharmacy? ESCP, http://www.escpweb.org/cms/Clinical_pharmacy.
  6. W. D. Schweickert and J. P. Kress, “Strategies to optimize analgesia and sedation,” Critical Care, vol. 12, supplement 3, p. S6, 2008. View at Publisher · View at Google Scholar · View at PubMed
  7. J. P. Kress, A. S. Pohlman, M. F. O'Connor, and J. B. Hall, “Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation,” New England Journal of Medicine, vol. 342, no. 20, pp. 1471–1477, 2000. View at Publisher · View at Google Scholar · View at PubMed
  8. R. Kuhlen and C. Putensen, “Remifentanil for analgesia-based sedation in the intensive care unit,” Critical Care, vol. 8, no. 1, pp. 13–14, 2004. View at Publisher · View at Google Scholar · View at PubMed
  9. M. Cigada, D. Corbella, G. Mistraletti et al., “Conscious sedation in the critically ill ventilated patient,” Journal of Critical Care, vol. 23, no. 3, pp. 349–353, 2008. View at Publisher · View at Google Scholar · View at PubMed
  10. S. B. Akıncı, F. Sarıcaoğlu, M. Kanbak, et al., “Remifentanil ve fentanilin yoğun bakım hastalarında analjezi bazlı sedasyon karşılaştırılması,” Anestezi Dergisi, vol. 13, no. 3, pp. 182–188, 2005.
  11. A. Karabinis, K. Mandragos, S. Stergiopoulos et al., “Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial,” Critical Care, vol. 8, no. 4, pp. 268–280, 2004.
  12. Q.-Y. Yang, F.-S. Xue, X. Liao et al., “Comparison of bolus remifentanil versus bolus fentanyl for blunting cardiovascular intubation responses in children: a randomized, double-blind study,” Chinese Medical Journal, vol. 122, no. 1, pp. 44–50, 2009. View at Publisher · View at Google Scholar
  13. D. Breen, A. Karabinis, M. Malnrain, et al., “Decreased duration of mechanical ventilation when comparing analgesia-based sedation using remifentanil with standart hypnotic-based sedation for up to 10 days in intensive care unit patients: a randomised, controlled trial,” Critical Care, vol. 9, pp. 200–210, 2005.
  14. V. Bonfreschi, E. Giuliani, F. C. Malagnino et al., “Analgesia during abdominal aortic aneurysm endovascular repair: remifentanil vs. fentanyl-midazolam-a randomized controlled trial,” European Journal of Anaesthesiology, vol. 26, no. 9, pp. 782–787, 2009. View at Publisher · View at Google Scholar · View at PubMed
  15. R. R. Riker, J. T. Picard, and G. L. Fraser, “Prospective evaluation of the sedation-agitation scale for adult critically ill patients,” Critical Care Medicine, vol. 27, no. 7, pp. 1325–1329, 1999. View at Publisher · View at Google Scholar
  16. J. A. Botha and P. Mudholkar, “The effect of a sedation scale on ventilation hours, sedative, analgesic and inotropic use in an intensive care unit,” Critical Care and Resuscitation, vol. 6, no. 4, pp. 253–257, 2004.
  17. M. B. Amor, R. Ouezini, K. Lamine, M. Barakette, I. Labbène, and M. Ferjani, “Arrêt journalier delasédation enréanimation chezl'insuffisant rénal: rémifentanil-midazolam versus fentanyl-midazolam,” Annales Francaises d'Anesthesie et de Reanimation, vol. 26, no. 12, pp. 1041–1044, 2007. View at Publisher · View at Google Scholar · View at PubMed
  18. T. Matthey, M. Schill, and B. Muellejans, “Earlier discharge from ICU with remifentanil / propofol versus fentanyl/midazolam,” Journal of Intensive Care Medicine, vol. 30, pp. 49–51, 2004.
  19. C. L. Westmoreland, J. F. Hoke, P. S. Sebel, C. C. Hug, and K. T. Muir, “Pharmacokinetics of remifentanil (GI87084B) and its major metabolite (GI90291) in patients undergoing elective inpatient surgery,” Anesthesiology, vol. 79, no. 5, pp. 893–903, 1993.
  20. V. U. Navapurkar, S. Archer, S. K. Gupta, K. T. Muir, N. Frazer, and G. R. Park, “Metabolism of remifentanil during liver transplantation,” British Journal of Anaesthesia, vol. 81, no. 6, pp. 881–886, 1998.
  21. M. Malbrain, A. Karabinis, R. Morais, et al., “Decreased time on mechanical ventilation using remifentanil-based analgesia and sedation,” Critical Care, vol. 8, no. 3, pp. 238–242, 2004.
  22. Y. Shirasawa, M. Matsumoto, M. Yoshimura, et al., “Does high-dose opioid anesthesia exacerbate ischemic spinal cord injury in rabbits?” Journal of Anesthesia, vol. 23, pp. 242–248, 2009.
  23. C. A. Bond, C. L. Raehl, M. E. Pitterle, and T. Franke, “Health care professional staffing, hospital characteristics, and hospital mortality rates,” Pharmacotherapy, vol. 19, no. 2, pp. 130–138, 1999. View at Publisher · View at Google Scholar
  24. L. L. Leape, D. J. Cullen, M. D. Clapp et al., “Pharmacist participation on physician rounds and adverse drug events in the intensive care unit,” Journal of the American Medical Association, vol. 282, no. 3, pp. 267–270, 1999. View at Publisher · View at Google Scholar
  25. G. T. Schumock, P. D. Meek, P. A. Ploetz, and L. C. Vermeulen, “Economic evaluations of clinical pharmacy services,” Pharmacotherapy, vol. 16, no. 6 I, pp. 1188–1208, 1996.
  26. G. M. Hawksworth, A. J. Corltt, D. J. Wright, et al., “Clinical pharmacy intervations by community pharmacists during the dispensing process,” British Journal of Clinical Pharmacology, vol. 47, pp. 695–700, 1999.
  27. J. Marshall, A. Christine, and A. C. Theodore, “Impact of a clinical pharmacist-enforced intensive care unit sedation protocol on duration of mechanical ventilation and hospital stay,” Critical Care Medicine, vol. 36, no. 2, pp. 427–433, 2008. View at Publisher · View at Google Scholar · View at PubMed