Evaluation of Lercanidipine in Paclitaxel-Induced Neuropathic Pain Model in Rat: A Preliminary Study

Table 1

Effect of lercanidipine in various doses on Tail flick latency (second) in paclitaxel-induced neuropathic rats. Data are expressed as mean ± SD.

Day	Control (𝑛=6)	Paclitaxel 1 mg/kg (𝑛=6)	Lercanidipine 0.5 μg/kg (𝑛=6)	Lercanidipine 1.0 μg/kg (𝑛=6)	Lercanidipine 2.5 μg/kg (𝑛=6)
0	10.19±0.73	13±1.55	12.89±1.63	11.11±1.52	11.17±1.28
7	10.83±1.26	11.72±1.22	12.06±0.83	12.00±1.19	10.25±0.87
14	10.72±1.27	9.6±1.02 *	10.72±1.31 *	12.44±2.04^#	12.05±.75^#
21	10.97±1.31	8.86±0.98 *	10.33±1.31 *	13.56±1.93^#	11.78±2.05^#
28	10.72±2.04	8.36±.64^∗	9.5±.68^∗	12.67±1.05^#	12.44±1.38^#

^∗𝑃<0.001 compared to 0 day, ^#𝑃<0.01 compared to paclitaxel group.