| | Drug | Dosage (per day) | Common side effects |
| | Antidepressants | | Sedation, weight gain, anticholinergic effects, sexual dysfunction, arrhythmia (side effects most prominent Sedation, weight gain, anticholinergic effects, sexual dysfunction, arrhythmia (side effects most prominent with amitriptyline) | | Amitriptyline (Elavil) | 20–150 mg | | Nortriptyline (Aventyl) | 20–150 mg | | Desipramine (Norpramin) | 20–200 mg | | Duloxetine (Cymbalta) | 60–120 mg | | Anticonvulsants | | | | Gabapentin (Neurontin) | 600–3,600 mg | Sedation, dizziness, peripheral edema, weight gain | | Pregabalin (Lyrica) | 150–600 mg | Similar to gabapentin | | Topiramate (Topamax) | 25–400 mg | Weight loss, sedation, cognitive slowing, renal stones, paresthesias | | Lamotrigine (Lamictal) | 25–400 mg | Stevens-Johnson syndrome, rash, dizziness, nausea, sedation | | Carbamazepine (Tegretol) | 200–1,200 mg | Dizziness, sedation, ataxia, aplastic anemia, liver enzyme elevation | | Oxcarbazepine (Trileptal) | 600–2,400 mg | Dizziness, nausea, fatigue, leukopenia | | Topical anesthetics | | | | 5% Lidocaine patch (Lidoderm) | Every 12 hours | Local edema, burning, erythema | | 0.075% Capsaicin patch | Three or four times a day | Burning | | Opioids, opioid agonists | | | | Tramadol (Ultram) | 100–400 mg | Sedation, dizziness, seizures, nausea, constipation | | Oxycodone (Oxycontin) | 10–100 mg | Sedation, constipation, nausea; potential for addiction and abuse |
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