Efficacy and Safety of Duloxetine in Patients with Chronic Low Back Pain Who Used versus Did Not Use Concomitant Nonsteroidal Anti-Inflammatory Drugs or Acetaminophen: A Post Hoc Pooled Analysis of 2 Randomized, Placebo-Controlled Trials

Table 1

Patient disposition.

	NSAID/APAP user			NSAID/APAP nonuser
	Duloxetine; 𝑁=137; n (%)	Placebo; 𝑁=82; n (%)	P value	Duloxetine; 𝑁=206; n (%)	Placebo; 𝑁=156; n (%)	P value
Completed study	90 (65.7)	63 (76.8)	.10	136 (66.0)	117 (75.0)	.08
Reason for discontinuation:
Adverse event	21 (15.3)	5 (6.1)	.051	39 (18.9)	12 (7.7)	.002
Lack of efficacy	7 (5.1)	4 (4.9)	1.00	5 (2.4)	7 (4.5)	.38
Lost to follow up	5 (3.6)	0	.16	7 (3.4)	3 (1.9)	.53
Protocol violation	5 (3.6)	4 (4.9)	.73	5 (2.4)	2 (1.3)	.70

Abbreviation: APAP, acetaminophen; NSAID, nonsteroidal anti-inflammatory drug.