Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome

Figure 1

Increases in leukocyte gene expression at 30 minutes, 8 hours, 24 hours, and 48 hours after moderate intensity exercise in healthy controls (top), CFS+FMS patients (middle), and CFS-only patients (bottom). Data for each gene (see color codes) are depicted as fold increases from preexercise baseline at each of the 4 sampling times; thus, 2.0 = twice as much expression as at baseline, and so forth. CFS+FMS and CFS only significantly greater than controls for P2X4, P2X5, TRPV1, α-2A, β-1, β-2 adrenergic receptors, COMT, and IL10 assessed as area under the curve across all 4 postexercise sampling times (P < 0.05). CFS+FMS greater than CFS-only and controls for ASIC3 (P < 0.05). Data are adapted from results reported by Light et al. [89].