Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome

Figure 2

Increases in leukocyte gene expression at 30 minutes, 8 hours, 24 hours, and 48 hours after moderate intensity exercise in healthy controls (top), FMS only patients (upper middle), multiple sclerosis patients (lower middle), and after higher intensity exercise in healthy controls (bottom). FMS-only do not differ from moderate exercise controls in any gene. MS patients significantly greater than moderate exercise controls for α-2A, β-1 and β-2 adrenergic receptors (P < 0.05). High-intensity controls significantly greater than moderate intensity controls for adrenergic receptors, LTα and IL10 (P < 0.05) but not for any sensory gene. CFS+FMS combined with CFS-only patients from Figure 1 significantly greater than high intensity controls for ASIC3, P2X4, TRPV1, α-2A and β-2 adrenergic receptors, and COMT (P < 0.05). Data are adapted from Light et al. [89], White et al. [90], and unpublished observations.