Research Article

The Effect of Topical Local Anesthetics on Thermal Pain Sensitivity in Patients with Irritable Bowel Syndrome

Table 5

Average time to a pain rating of “10%” and eVAS ratings (±SD) of a 30 second pulse of 47.0°C on the left thenar (Trial 2). The baseline session represents data collapsed across sessions 2, 5, and 7. Pain intensity was continuously rated on a 0 to 100 scale. Time to obtain a rating of “10%” is measured in seconds. Continuous ratings of thermal pain were analyzed to determine peak (highest pain rating during the trial) and average (i.e., average amount of pain reported during the trial) pain.

IBSCONTROL
BaselinePlaceboRectalOralBaselinePlaceboRectalOral

Time to 10% (sec)4.7 (1.6)4.5 (1.4)4.2 (1.3)4.6 (1.0)7.8 (4.0)6.1 (3.2)6.4 (2.4)6.4 (3.6)
Peak Pain69.2 (21.4)65.9 (32.3)71.1 (24.7)63.4 (22.9)46.1 (20.7)46.9 (20.0)50.4 (23.9)51.4 (23.6)
Average pain41.5 (14.0)44.6 (27.7)44.3 (17.8)39.0 (15.6)24.3 (13.4)22.7 (17.1)28.3 (17.8)29.5 (17.2)