Immune Biomarker Response Depends on Choice of Experimental Pain Stimulus in Healthy Adults: A Preliminary Study
Table 2
Bivariate correlations between cortisol, catastrophizing and pain ratings with immune biomarker concentrations changes (post-pre) after cold pain (ΔCPT) and hot pain (ΔFHP) stimulation.
Cortisol
Cortisol
PCS€
PCS
PPR£
PPR
ΔCPT*
ΔFHP*
ΔCPT
ΔFHP
ΔCPT
ΔFHP
r (P-value)
r (P-value)
r (P-value)
r (P-value)
r (P-value)
r (P-value)
IL-1β
−0.57 (0.140)
0.31 (0.455)
−0.64 (0.087)
0.22 (0.601)
−0.35 (0.395)
0.64 (0.087)
TNF-α
−0.38 (0.353)
0.20 (0.635)
−0.29 (0.486)
0.18 (0.670)
−0.46 (0.251)
0.26 (0.534)
IFN-γ
−0.34 (0.410)
0.24 (0.567)
−0.18 (0.670)
0.15 (0.723)
−0.25 (0.550)
0.63 (0.094)
IL-8
−0.70 (0.053)
0.17 (0.687)
−0.52 (0.187)
0.22 (0.601)
−0.50 (0.207)
0.64 (0.087)
IL-12
−0.46 (0.251)
0.25 (0.550)
−0.35 (0.395)
0.16 (0.705)
−0.41 (0.313)
0.65 (0.081)
MCP-1
−0.58 (0.132)
0.02 (0.963)
−0.36 (0.381)
0.33 (0.425)
−0.49 (0.218)
0.85 (0.008)
αMSH
0.05 (0.906)
0.20 (0.635)
0.08 (0.851)
0.00 (0.998)
0.17 (0.687)
0.13 (0.759)
IL-6
0.64 (0.087)
0.50 (0.207)
0.44 (0.275)
0.16 (0.705)
0.55 (0.158)
0.65 (0.081)
IL-10
0.30 (0.470)
−0.36 (0.381)
0.22 (0.601)
−0.49 (0.218)
0.35 (0.395)
−0.64 (0.087)
*Positive values indicate an increase in biomarker concentrations, while negative values represent a decrease in biomarker concentrations. €PCS = Pain Catastrophizing Scale scores. £PPR = Peak Pain Ratings.
