A Comprehensive Evaluation of Standardized Assessment Tools in the Diagnosis of Fibromyalgia and in the Assessment of Fibromyalgia Severity

Table 2

Assessments used to evaluate fibromyalgia symptom severity in medication trials.

Symptom	Medication used in treatment trials
	Pregabalin	Duloxetine	Milnacipran	Sodium oxybate
Fatigue	MAF	MFI	MFI	Fatigue VAS
Fibrofog	—	—	MASQ	—
Sleep	MOS-Sleep	—	JSS, MOS-sleep	FOSQ, JSS
Depression	BDI, HADS-D	BDI-II, HAMD17	BDI	—
Anxiety	HADS-A	Beck Anxiety Inv.	Beck anxiety inv.	—
Pain	Pain VAS, Pain NRS	BPI-mod short form	Pain VAS, McGill pain quest.	Pain VAS
Physical disability	FIQ, F-HAQ	FIQ, SDS	FIQ, MDHAQ	FIQ
Global/QOL	FIQ, CGI-C, PGI-C, SF-36	EQ-5D, FIQ, CGI-S, PGI-I, SF-36	FIQ, PGI-C, SF-36	FIQ, CGI-C, CGI-S, PGI-C, SF-36
Tenderness	MTPS-FIS	—	—	TPI

BDI: beck depression inventory, BPI: brief pain inventory, CGI-C: clinician global impression of change, CGI-S: clinician global impression of severity, EQ-5D: EUROQOL 5-D qUESTIONNAIRE, F-HAQ: fibromyalgia health assessment questionnaire, FIQ: fibromyalgia impact questionnaire, FIS: fibromyalgia intensity scale, FOSQ: Functional outcomes of sleep questionnaire, HADS: hospital anxiety and depression scale (-D denotes depression subscale, -A denotes anxiety subscale), HAMD17: 17-item hamilton rating scale for depression, Inv.: inventory, JSS: jenkins sleep scale, MAF: multidimensional assessment of fatigue, MASQ: multiple abilities self-report questionnaire, MDHAQ: multi-dimensional health assessment questionnaire, MFI: multidimensional fatigue inventory, MOS-sleep: medical outcomes studies sleep scale, MTPS: manual tender point survey, NRS: numeric rating scale, PGI-C: patient global impression of change, PGI-I: patient global impression of improvement, QOL: quality of life, QUEST.: questionnaire, SDS: sheehan disability scale, SF-36: short form health survey, TPI: tender point index, VAS: visual analogue scale.