- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Pain Research and Treatment
Volume 2012 (2012), Article ID 817347, 9 pages
ASICs Do Not Play a Role in Maintaining Hyperalgesia Induced by Repeated Intramuscular Acid Injections
1Graduate Program in Physical and Rehabilitation Science, University of Iowa, 1-252 MEB, Iowa City, IA 52242, USA
2Department of Internal Medicine, University of Iowa, E315 GH, Iowa City, IA 52242, USA
3Department of Chemistry, University of Utah, 315 S 1400 E RM 2020, Salt Lake City, UT 84112, USA
4Department of Anesthesia, University of Utah, 30 N 1900 E RM 3C444, Salt Lake City, UT 84132, USA
Received 14 June 2011; Revised 29 August 2011; Accepted 4 September 2011
Academic Editor: Brian E. Cairns
Copyright © 2012 Mamta Gautam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. Waldmann and M. Lazdunski, “H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels,” Current Opinion in Neurobiology, vol. 8, no. 3, pp. 418–424, 1998.
- P. W. Reeh and K. H. Steen, “Tissue acidosis in nociception and pain,” Progress in Brain Research, vol. 113, pp. 143–151, 1996.
- L. A. Frey Law, K. A. Sluka, T. McMullen, J. Lee, L. Arendt-Nielsen, and T. Graven-Nielsen, “Acidic buffer induced muscle pain evokes referred pain and mechanical hyperalgesia in humans,” Pain, vol. 140, no. 2, pp. 254–264, 2008.
- K. A. Sluka, O. C. Winter, and J. A. Wemmie, “Acid-sensing ion channels: a new target for pain and CNS diseases,” Current Opinion in Drug Discovery and Development, vol. 12, no. 5, pp. 693–704, 2009.
- J. Jasti, H. Furukawa, E. B. Gonzales, and E. Gouaux, “Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH,” Nature, vol. 449, no. 7160, pp. 316–323, 2007.
- C. J. Benson, J. Xie, J. A. Wemmie et al., “Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 4, pp. 2338–2343, 2002.
- K. A. Sluka, R. Radhakrishnan, C. J. Benson et al., “ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation,” Pain, vol. 129, no. 1-2, pp. 102–112, 2007.
- M. Ikeuchi, S. J. Kolker, and K. A. Sluka, “Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis,” Journal of Pain, vol. 10, no. 3, pp. 336–342, 2009.
- M. Ikeuchi, S. J. Kolker, L. A. Burnes, R. Y. Walder, and K. A. Sluka, “Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice,” Pain, vol. 137, no. 3, pp. 662–669, 2008.
- R. Y. Walder, L. A. Rasmussen, J. D. Rainier, A. R. Light, J. A. Wemmie, and K. A. Sluka, “ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury,” Journal of Pain, vol. 11, no. 3, pp. 210–218, 2010.
- M. P. Price, S. L. McIlwrath, J. Xie et al., “The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice,” Neuron, vol. 32, no. 6, pp. 1071–1083, 2001.
- C. C. Chen, A. Zimmer, W. H. Sun, J. Hall, M. J. Brownstein, and A. Zimmer, “A role for ASIC3 in the modulation of high-intensity pain stimuli,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 13, pp. 8992–8997, 2002.
- A. A. Staniland and S. B. McMahon, “Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test,” European Journal of Pain, vol. 13, no. 6, pp. 554–563, 2009.
- E. Deval, J. Noël, N. Lay et al., “ASIC3, a sensor of acidic and primary inflammatory pain,” EMBO Journal, vol. 27, no. 22, pp. 3047–3055, 2008.
- J. Mamet, A. Baron, M. Lazdunski, and N. Voilley, “Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels,” Journal of Neuroscience, vol. 22, no. 24, pp. 10662–10670, 2002.
- S. Ohtori, G. Inoue, T. Koshi et al., “Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats,” Spine, vol. 31, no. 18, pp. 2048–2052, 2006.
- Y. Uchiyama, C. C. Cheng, K. G. Danielson et al., “Expression of Acid-Sensing Ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling,” Journal of Bone and Mineral Research, vol. 22, no. 12, pp. 1996–2006, 2007.
- N. Voilley, J. de Weille, J. Mamet, and M. Lazdunski, “Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors,” Journal of Neuroscience, vol. 21, no. 20, pp. 8026–8033, 2001.
- M. Gautam, C. J. Benson, and K. A. Sluka, “Increased response of muscle sensory neurons to decreases in pH after muscle inflammation,” Neuroscience, vol. 170, no. 3, pp. 893–900, 2010.
- K. A. Sluka, M. P. Price, J. A. Wemmie, and M. J. Welsh, “ASIC3, but not ASIC1, channels are involved in the development of chronic muscle pain,” in Proceedings of the 10th World Congress on Pain, J. O. Dostrovsky, D. B. Carr, and M. Koltzenburg, Eds., pp. 71–79, IASP Press, Seattle, 2003.
- G. R. Dubé, S. G. Lehto, N. M. Breese et al., “Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels,” Pain, vol. 117, no. 1-2, pp. 88–96, 2005.
- K. A. Sluka, A. Kalra, and S. A. Moore, “Unilateral intramuscular injections of acidic saline produce a bilateral, long-lasting hyperalgesia,” Muscle & Nerve, vol. 24, no. 1, pp. 37–46, 2001.
- K. A. Sluka, M. P. Price, N. M. Breese, C. L. Stucky, J. A. Wemmie, and M. J. Welsh, “Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1,” Pain, vol. 106, no. 3, pp. 229–239, 2003.
- M. J. Caterina, A. Leffler, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius, “The capsaicin receptor: a heat-activated ion channel in the pain pathway,” Nature, vol. 389, no. 6653, pp. 816–824, 1997.
- E. Lingueglia, “Acid-sensing ion channels in sensory perception,” Journal of Biological Chemistry, vol. 282, no. 24, pp. 17325–17329, 2007.
- M. Hesselager, D. B. Timmermann, and P. K. Ahring, “pH dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits,” Journal of Biological Chemistry, vol. 279, no. 12, pp. 11006–11015, 2004.
- J. Karczewski, R. H. Spencer, V. M. Garsky et al., “Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2,” British Journal of Pharmacology, vol. 161, no. 4, pp. 950–960, 2010.
- A. N. Nielsen, C. Mathiesen, and G. Blackburn-Munro, “Pharmacological characterisation of acid-induced muscle allodynia in rats,” European Journal of Pharmacology, vol. 487, no. 1–3, pp. 93–103, 2004.
- T. Yokoyama, K. M. Audette, and K. A. Sluka, “Pregabalin Reduces Muscle and Cutaneous Hyperalgesia in Two Models of Chronic Muscle Pain in Rats,” Journal of Pain, vol. 8, no. 5, pp. 422–429, 2007.
- K. A. Sluka, J. J. Rohlwing, R. A. Bussey, S. A. Eikenberry, and J. M. Wilken, “Chronic muscle pain induced by repeated acid injection is reversed by spinally administered μ- and δ-, but not κ-, opioid receptor agonists,” Journal of Pharmacology and Experimental Therapeutics, vol. 302, no. 3, pp. 1146–1150, 2002.
- A. Miranda, S. Peles, C. Rudolph, R. Shaker, and J. N. Sengupta, “Altered visceral sensation in response to somatic pain in the rat,” Gastroenterology, vol. 126, no. 4, pp. 1082–1089, 2004.
- D. A. Skyba, T. L. Lisi, and K. A. Sluka, “Excitatory amino acid concentrations increase in the spinal cord dorsal horn after repeated intramuscular injection of acidic saline,” Pain, vol. 119, no. 1–3, pp. 142–149, 2005.
- R. Radhakrishnan and K. A. Sluka, “Increased glutamate and decreased glycine release in the rostral ventromedial medulla during induction of a pre-clinical model of chronic widespread muscle pain,” Neuroscience Letters, vol. 457, no. 3, pp. 141–145, 2009.
- D. V. Tillu, G. F. Gebhart, and K. A. Sluka, “Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult,” Pain, vol. 136, no. 3, pp. 331–339, 2008.
- R. Gandhi, J. M. Ryals, and D. E. Wright, “Neurotrophin-3 reverses chronic mechanical hyperalgesia induced by intramuscular acid injection,” Journal of Neuroscience, vol. 24, no. 42, pp. 9405–9413, 2004.
- D. A. Skyba, E. W. King, and K. A. Sluka, “Effects of NMDA and non-NMDA ionotropic glutamate receptor antagonists on the development and maintenance of hyperalgesia induced by repeated intramuscular injection of acidic saline,” Pain, vol. 98, no. 1-2, pp. 69–78, 2002.
- L. F. S. da Silva, J. M. DeSantana, and K. A. Sluka, “Activation of NMDA receptors in the brainstem, rostral ventromedial medulla, and nucleus reticularis gigantocellularis mediates mechanical hyperalgesia produced by repeated intramuscular injections of acidic saline in rats,” Journal of Pain, vol. 11, no. 4, pp. 378–387, 2010.
- M. K. Hoeger-Bement and K. A. Sluka, “Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections,” Journal of Neuroscience, vol. 23, no. 13, pp. 5437–5445, 2003.
- D. C. Molliver, D. C. Immke, L. Fierro, M. Paré, F. L. Rice, and E. C. McCleskey, “ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons,” Molecular Pain, vol. 1, article 35, 2005.
- N. K. Sharma, J. M. Ryals, H. Liu, W. Liu, and D. E. Wright, “Acidic saline-induced primary and secondary mechanical hyperalgesia in mice,” Journal of Pain, vol. 10, no. 12, pp. 1231–1241, 2009.
- S. Peles, J. Petersen, R. Aviv et al., “Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation,” American Journal of Physiology, vol. 285, no. 3, pp. G577–G585, 2003.