Matrix Metalloproteinases in Neuropathic Pain and Migraine: Friends, Enemies, and Therapeutic Targets

Table 1

Matrix metalloproteinases modulate tissue structure and cellular activities by participating in complex biological processes.

Developing tissue; (normal and injured)	Adult tissue; (normal and injured)
(i) Embryogenesis and morphogenesis; (ii) Cell migration, differentiation, and death (including neuronal migration, dendritogenesis, synaptogenesis, and myelination)	(i) Normal tissue maintenance and remodeling; (ii) Wound healing; (iii) Angiogenesis; (iv) Neuroplasticity and neurorepair; (v) Leukocyte adherence and transmigration; (vi) Release of biologically active molecules (e.g., growth factors, inflammatory modulators); (vii) Vasogenic edema; (viii) Tumor cell survival and metastasis; (ix) Cell growth inhibition