Polymorphism of μ-Opioid Receptor Gene (OPRM1:c.118A>G) Might Not Protect against or Enhance Morphine-Induced Nausea or Vomiting

Table 4

Tests for the relations between morphine consumption versus side effects.

		Morphine consumption (mg)	P value
Nausea	Severe	20.5 (13.6, 35.1)	0.033*
	Mild	21.0 (16.0, 32.1)
	None	29.0 (21.0, 39.0)
Nausea	Yes	21.0 (16.0, 33.1)	0.010*
	No	29.0 (21.0, 39.0)
Vomiting	Severe	19.1 (11.1, 23.1)^†	0.014*
	Mild	20.6 (15.5, 32.1)
	None	29.5 (20.0, 37.1)
Vomiting	Yes	19.1 (15.0, 29.0)	0.004*
	No	29.5 (20.0, 37.1)
Nausea or vomiting	Yes	21.0 (16.0, 34.0)	0.018*
	No	28.6 (21.0, 39.2)

∗Indicated that there is significant difference in morphine consumption between various categories in the corresponding side effect.
†Indicated that there is significant difference in morphine consumption between those with severe vomiting and without vomiting.