Plasma Amino Acids Changes in Complex Regional Pain Syndrome

Table 2

Plasma amino acid levels.

Amino acid	Controls (𝑛=60)	CRPS (𝑛=160)	𝑃
	(umoles/L)	(umoles/L)
L-Aspartate	7.47±0.36	𝟗.𝟐𝟕±𝟎.𝟑𝟎	0.00473
L-Glutamate	52.51±4.29	𝟕𝟕.𝟐𝟐±𝟑.𝟓𝟐	0.00057
L-Asparagine	51.91±1.69	47.59±0.93
L-Serine	107.75±3.54	100.16±2.23
L-Glutamine	572.73±13.2	579.40±9.74
D-Serine	1.94±0.07	2.06±0.05
L-Citrulline	28.17±1.20	30.58±0.84
L-Threonine	135.07±5.04	133.34±3.08
Glycine	302.99±12.6	318.87±9.31
L-Histidine	65.88±2.28	68.07±1.91
L-Arginine	67.49±3.33	𝟒𝟖.𝟖𝟐±𝟏.𝟓𝟗	0.000001
L-Alanine	426.06±14.2	447.11±11.1
Taurine	67.46±2.61	72.87±2.29
L-Tyrosine	80.72±2.82	77.39±1.77
L-Valine	260.67±8.54	243.64±5.46
L-Methionine	23.81±0.87	20.76±0.50
L-Isoleucine	74.93±3.51	66.89±1.90
L-Tryptophan	41.91±1.25	𝟑𝟔.𝟗𝟔±𝟎.𝟖𝟐	0.04210
L-Phenylalanine	48.23±1.45	46.53±0.92
L-Leucine	122.71±4.70	108.53±2.57
L-Ornithine	70.29±3.53	𝟗𝟒.𝟑𝟖±𝟑.𝟏𝟐	0.00002
L-Lysine	160.89±5.76	155.57±3.37
L-Kynurenine	1.79±0.07	1.80±0.06

This table lists the plasma amino acid levels in CRPS and healthy control subjects. All values are given in micromoles per liter ± the standard error of the mean. Significant difference in plasma amino acid levels between the control and CRPS groups was determined with the Student’s 𝑡-test adjusted for multiple testing (Bonferroni). Bonferroni adjusted probability values (the 𝑃 value from the Student’s 𝑡-test multiplied by 23, the number of amino acids evaluated) less than 0.05 are highlighted in bold.