Reconstruction of Mandibular Defects Using Bone Morphogenic Protein: Can Growth Factors Replace the Need for Autologous Bone Grafts? A Systematic Review of the Literature

Table 2

Analysis of the articles.

	Moghadam et al. [16]	Herford et al. [3]	Clokie and Sándor [17]	Herford and Boyne [4]	Carter et al. [18]	Herford [1]	Glied and Kraut [19]	Herford and Cicciù [15]
Type of study	Case report	Case report	Case report	Case review	Case report	Case report	Case report	Case report
No. of patients	1	1	10	14	5	2	3	1
Type of BMP used	Human BMP	rh BMP 2	rh BMP 7	rh BMP 2	rh BMP 2	rh BMP 2	rh BMP 2	rh BMP 2
Size of defect	6 cm	Not declared	3–9 cm	4–8 cm	5 cm	Not declared	4.5–8 cm	Not declared
BMP dose	200 mg	8 mg	n.d.	6 mg	8.4 mg/12 mg	12 mg	24 mg	4.2 mg
Carrier	Poloxamer-based gel	ACS	None	ACS	ACS	ACS	ACS	ACS
Graft extender	None	None	DBM	None	DBM	DBM	None	ICBG
Method of measuring	CT scan + biopsy	CT scan	CT scan	CT scan	CT scan	CT scan	CT scan	CT scan
Followup	9 months	2 months	9–12 months	6 months	8–22 months	8-9 months	6–12 months	4 months
Etiology	Ameloblastoma	Juvenile ossifing fibroma	Ameloblastoma/; Osteomyelitis	Neoplastic disease/; Osteomyelitis	Trauma/; Cyst	Ameloblastoma	Ameloblastoma	Giant cells tumor
Implant rehabilitation	None	None	4 of 10 patients	None	None	1 of 2 patient	None	None
Complications	None	None	None	None	2 patients failed	None	Complete failure	None