The Role of Current Techniques and Concepts in Peripheral Nerve Repair

Figure 1

(a) In the PNS, support cells aid neuronal regeneration. Proliferating Schwann cells, macrophages, and monocytes work together to remove myelin debris, release neurotrophins, and lead axons toward their synaptic targets, resulting in restored neuronal function. (b) In the CNS, however, the few neurons that survive axotomy attempt regeneration and subsequently meet an impenetrable glial scar composed myelin and cellular debris, as well as astrocytes, oligodendrocytes, and microglia. Fibroblasts, monocytes, and macrophages may also be present in the glial scar. Consequently, regenerating neurons in the spinal cord are blocked from reaching their synaptic target.

(a)

(b)