An Insight into the Sialomes of Bloodsucking Heteroptera

Table 3

Classification of the protein families relevant to secreted products in the Hemiptera/Heteroptera.

Classification	No. of proteins	Genera found^1	Function characterized?^2	References
Ubiquitous protein families
Enzymes
Cimex apyrase	1	C, R(?)	Y	[26, 50]
5^′-nucleotidase	6	T	Y	[12, 13, 51]
Cimex NUDIX hydrolase	3	C
Secreted esterase	5	C, T
Inositol phosphate phosphatases including Cimex nitrophorins	24	C, T, R	Y/N	[8, 27, 28]
Serine proteases	17	C, T	Y/N	[30]
Chitinase	1	O
Other enzymes	4	T, O
Protease inhibitor domains
Kazal domain containing proteins	13	T
Serpin	1	C
Pacifastin-related peptide	1	O
Cystatin	5	O
Lipocalins	331	T, R	Y/N	[2, 4–7, 11, 14, 15, 19–21, 23, 43, 52–55]
Salivary OBP	19	C, T, R
Salivary antigen 5 family	22	C, T, R
Triatoma dimidiata lectin	2	T
Immunity related
Lysozyme	4	C
Defensin	1	T
Histidine-rich peptide	1	T
Immune-related conserved insect protein	1	T
Arthropod or insect specific families
Cuticle-like proteins and conserved mucins	5	T
Conserved insect secreted protein family	6	C, T, O
Mys2 family	3	R, T
Cimex-Triatoma family	3	C, T
Other individual proteins of conserved insect  families	4	T
Hemiptera specific families
Mys3/hemolysin-like family	16	T, R, O
Triatoma-specific families
Trialysin	8	T	Y	[17, 18]
Short trialysin	6	T
Triatoma matogrossensis family	2	T
Triatoma matogrossensis family 2	2	T
Orphan Triatoma proteins	19	T
Rhodnius-specific families
Orphan Rhodnius proteins, include  low-complexity proteins	3	R
Cimex-specific proteins
Cimex mucin family	2	C
Orphan Cimex proteins	1	C
Oncopeltus-specific families
Oncopeltus family	3	O
Oncopeltus family 2	2	O
Orphan Oncopeltus protein	12	O
Total	559

¹C: Cimex; T: Triatoma/Dipetalogaster/Panstrongylus; R: Rhodnius; O: Oncopeltus.
²Y: yes; Y/N: characterization of a few or a single member of the family.