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Volume 2013 (2013), Article ID 849346, 6 pages
Association between Neurocognitive Impairment and the Short Allele of the 5-HTT Promoter Polymorphism in Depression: A Pilot Study
1Institute of Behavioural Sciences, University of Helsinki, P.O. Box 9, 00014 University of Helsinki, Finland
2Department of Pharmacology, Drug Development and Therapeutics, University of Turku, 20014 Turku, Finland
3Department of Psychiatry, Helsinki University Central Hospital, P.O. Box 590, 00029 HUS, Finland
4Department of Psychiatry, University of Helsinki, P.O. Box 22, 00014 University of Helsinki, Finland
Received 19 September 2012; Revised 20 November 2012; Accepted 20 November 2012
Academic Editor: José F. Navarro
Copyright © 2013 Hely Kalska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- H. O. F. Veiel, “A preliminary profile of neuropsychological deficits associated with major depression,” Journal of Clinical and Experimental Neuropsychology, vol. 19, no. 4, pp. 587–603, 1997.
- R. J. Porter, P. Gallagher, J. M. Thompson, and A. H. Young, “Neurocognitive impairment in drug-free patients with major depressive disorder,” British Journal of Psychiatry, vol. 182, pp. 214–220, 2003.
- K. B. Boone, I. M. Lesser, B. L. Miller et al., “Cognitive functioning in older depressed outpatients: relationship of presence and severity of depression to neuropsychological test scores,” Neuropsychology, vol. 9, no. 3, pp. 390–398, 1995.
- R. Purcell, P. Maruff, M. Kyrios, and C. Pantelis, “Neuropsychological function in young patients with unipolar major depression,” Psychological Medicine, vol. 27, no. 6, pp. 1277–1285, 1997.
- M. P. Austin, P. Mitchell, and G. M. Goodwin, “Cognitive deficits in depression: possible implications for functional neuropathology,” British Journal of Psychiatry, vol. 178, pp. 200–206, 2001.
- R. Elliott, “The neuropsychological profile in unipolar depression,” Trends in Cognitive Sciences, vol. 2, no. 11, pp. 447–484, 1998.
- A. R. Hariri and A. Holmes, “Genetics of emotional regulation: the role of the serotonin transporter in neural function,” Trends in Cognitive Sciences, vol. 10, no. 4, pp. 182–191, 2006.
- K.-P. Lesch, D. Bengel, A. Heils et al., “Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region,” Science, vol. 274, no. 5292, pp. 1527–1531, 1996.
- A. Caspi, K. Sugden, T. E. Moffitt et al., “Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene,” Science, vol. 301, no. 5631, pp. 386–389, 2003.
- K. Karg, M. Burmeister, K. Shedden, and S. Sen, “The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation,” Archives of General Psychiatry, vol. 68, no. 5, pp. 444–454, 2011.
- T. Canli and K. P. Lesch, “Long story short: the serotonin transporter in emotion regulation and social cognition,” Nature Neuroscience, vol. 10, no. 9, pp. 1103–1109, 2007.
- M. C. Eker, O. Kitis, H. Okur et al., “Smaller hippocampus volume is associated with short variant of 5-HTTLPR polymorphism in medication-free major depressive disorder patients,” Neuropsychobiology, vol. 63, no. 1, pp. 22–28, 2010.
- A. S. R. Sierksma, D. L. A. van den Hove, H. W. M. Steinbusch, and J. Prickaerts, “Major depression, cognitive dysfunction and Alzheimer's disease: is there a link?” European Journal of Pharmacology, vol. 626, no. 1, pp. 72–82, 2010.
- J. Borg, S. Henningsson, T. Saijo et al., “Serotonin transporter genotype is associated with cognitive performance but not regional 5-HT1A receptor binding in humans,” International Journal of Neuropsychopharmacology, vol. 12, no. 6, pp. 783–792, 2009.
- D. E. Anderson, T. A. Bell, and E. Awh, “Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory,” Journal of Cognitive Neuroscience, vol. 24, no. 5, pp. 1–8, 2012.
- M. Hamilton, “A rating scale for depression,” Journal of neurology, neurosurgery, and psychiatry, vol. 23, pp. 56–62, 1960.
- M. B. First, M. Gibbon, R. C. Spitzer, J. B. W. Williams, and L. S. Benjamin, Structured Clinical Interview for DSM-IV, Clinician Version (SCID-CV), American Psychiatric Press, Washington, DC, USA, 1997.
- M. B. First, M. Gibbon, R. C. Spitzer, J. B. W. Williams, and L. S. Benjamin, Structured Clinical Interview For DSM-IV Axis-II—Personality Disorders (SCID-II), American Psychiatric Press, Washington, DC, USA, 1997.
- A. T. Beck, R. Steer, and G. K. Brown, The Beck Depression Inventory-II Manual, Psychological Corporation, San Antonio, Tex, USA, 1996.
- A. T. Beck, A. Weissman, D. Lester, and L. Trexler, “The measurement of pessimism: the hopelessness scale,” Journal of Consulting and Clinical Psychology, vol. 42, no. 6, pp. 861–865, 1974.
- A. T. Beck, N. Epstein, G. Brown, and R. A. Steer, “An inventory for measuring clinical anxiety: psychometric properties,” Journal of Consulting and Clinical Psychology, vol. 56, no. 6, pp. 893–897, 1988.
- M. Lezak, D. B. Howieson, and D. W. Loring, Neuropsychological Assessment, Oxford University Press, New York, NY, USA, 2004.
- D. Wechsler, Manual for the Wechsler Adult Intelligence Scale—Revised, The Psychological Corporation, Cleveland, Ohio, USA, 1981.
- D. Wechsler, Manual For the Wechsler Memory Scale—Revised, The Psychological Corporation, San Antonio, Tex, USA, 1987.
- D. Wechsler, The Wechsler Memory Scale-III Manual, The Psychological Corporation, San Antonio, Tex, USA, 1997.
- R. M. Reitan and D. Wolfson, The Halsted-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation, Neuropsychology Press, Tucson, Ariz, USA, 1993.
- M. J. Anderson, “A new method for non-parametric multivariate analysis of variance,” Austral Ecology, vol. 26, no. 1, pp. 32–46, 2001.
- B. H. McArdle and M. J. Anderson, “Fitting multivariate models to community data: a comment on distance-based redundancy analysis,” Ecology, vol. 82, no. 1, pp. 290–297, 2001.
- B. F. J. Manly, Randomization, Bootstrap, and Monte Carlo Methods in Biology, Chapman & Hall, London, UK, 3rd edition, 2007.
- R. Development Core Team, “R: a language and environment for statistical computing,” R Foundation for Statistical Computing, Vienna, Austria, 2009, http://www.r-project.org/.
- J. Oksanen, F. Guillaume, R. Kindt, et al., “Vegan: community ecology package,” R package version 1. 17-2, 2010, http://CRAN.R-project.org/package=vegan/.
- A. C. Cameron and P. K. Trivedi, Regression Analysis of Count Data, Cambridge Press, New York,NY, USA, 1998.
- S. Marini, S. Bagnoli, V. Bessi et al., “Implication of serotonin-transporter (5-HTT) gene polymorphism in subjective memory complaints and mild cognitive impairment (MCI),” Archives of Gerontology and Geriatrics, vol. 52, no. 2, pp. e71–e74, 2011.
- R. O’Hara, J. Thompson, J. Flournoy, J. Hallmayer, and C. Depp, “HTTLPR Short allele, resilience, and successful aging in older adults,” American Journal of Geriatric Psychiatry, vol. 20, pp. 452–456, 2012.
- X. Hu, G. Oroszi, J. Chun, T. L. Smith, D. Goldman, and M. A. Schuckit, “An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk,” Alcoholism: Clinical and Experimental Research, vol. 29, no. 1, pp. 8–16, 2005.
- T. Frodl, P. Zill, T. Baghai et al., “Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression,” American Journal of Medical Genetics, Part B, vol. 147, no. 7, pp. 1003–1007, 2008.
- H. J. Cho, I. Meira-Lima, Q. Cordeiro et al., “Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis,” Molecular Psychiatry, vol. 10, no. 8, pp. 771–781, 2005.
- K. S. Kendler, C. O. Gardner, M. C. Neale, and C. A. Prescott, “Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?” Psychological Medicine, vol. 31, no. 4, pp. 617–625, 2001.
- A. R. Hariri, E. M. Drabant, K. E. Munoz et al., “A susceptibility gene for affective disorders and the response of the human amygdala,” Archives of General Psychiatry, vol. 62, no. 2, pp. 146–152, 2005.
- T. E. Goldberg and D. R. Weinberger, “Genes and the parsing of cognitive processes,” Trends in Cognitive Sciences, vol. 8, no. 7, pp. 325–336, 2004.