Variables Polypharmacy (%) COR, 95% CI AOR, 95% CI Yes No Sex Male 92 195 1.99 (1.19, 3.30) 1.16 (0.58, 2.31) Female 24 101 1.00 1.00 Ethnicity Amhara 37 75 1.07 (0.48, 2.35) 1.17 (0.46, 2.94) Oromo 32 116 0.60 (0.27, 1.31) 0.74 (0.29, 1.85) Tigre 10 11 1.97 (0.65, 5.89) 1.54 (0.43, 5.52) Gurage 25 68 0.80 (0.35, 1.81) 0.87 (0.82, 2.74) Others 12 26 1.00 1.00 Residence Urban 88 192 1.70 (1.04, 2.77) 1.50 (0.82, 2.74) Rural 28 104 1.00 1.00 Marital status Married 15 65 1.00 1.00 Single 81 189 1.86 (1.00, 3.45) 0.73 (0.37, 1.43) Separated 11 13 3.67 (1.37, 9.76) 2.11 (0.83, 5.35) Divorced 8 24 1.44 (0.54, 3.84) 0.80 (0.32, 2.02) Widowed 1 5 0.86 (0.09, 7.97) 0.64 (0.06, 5.97) Occupational status Employed 17 51 3.17 (0.66, 15.02) 2.60 (0.45, 14.93) Private business 18 52 3.29 (0.69, 15.53) 1.79 (0.30, 10.66) Daily laborer 11 26 4.02 (0.79, 20.28) 2.26 (0.35, 14.56) Jobless 66 130 4.82 (1.09, 21.33) 2.99 (0.52, 16.91) Student 2 18 1.06 (0.13, 8.31) 1.16 (0.11, 12.13) Housewife 2 19 1.00 1.00 Duration of illness <5 years 28 115 1.00 1.00 5–10 years 34 76 1.83 (1.03, 3.27) 0.72 (0.29, 1.75) >10 years 54 105 2.11 (1.24, 3.58) 0.43 (0.13,1.46) Duration of treatment <5 years 37 161 1.00 1.00 5–10 years 35 60 2.53 (1.46, 4.39) 1.93 >10 years 44 75 2.55 (1.52, 4.27) 2.24 Number of admissions None 65 225 1.00 1.00 One 20 46 1.51 (0.83, 2.72) 1.50 (0.80, 2.80) Two or more 31 25 4.29 (2.36, 7.78) 3.16 Substance use (Khat, alcohol, and tobacco) No 54 196 1.00 1.00 Yes 62 100 2.25 (1.45, 3.48) 1.69 Extra pyramidal side effect No 94 275 1.00 1.00 Yes 22 21 3.07 (1.61, 5.82) 2.76 Drug adherence Yes 52 191 1.00 1.00 No 64 105 2.24 (1.44, 3.46) 1.96