Research Article
Premature Calcifications of Costal Cartilages: A New Perspective
Table 2
Conditions that may lead to premature calcifications of costal cartilages.
| Clinical disorder | Presumed pathogenesis | References |
| Adolescent hyperthyroidism | Advanced bone maturation by toxic hormone doses | [1, 5, 6] |
| Exposure to corticoids | Complex findings in vitro; extensive research in earlier decades; direct influence on cartilage matrix | [7, 16, 17, 19] |
| Adrenogenital syndrome | Unknown | [8, 9] |
| Keutel syndrome | Autosomal recessive disorder with several anomalies; frequent consanguinity, description, 1971 | [10, 11] | Mutations in the matrix Gla protein gene (MGP) that acts as a calcification inhibitor (for details see [24]) | [24] |
| Porphyria | Unknown | This paper |
| Systemic conditions as chronic renal failure or autoimmune disorders | Unknown | [1] |
|
|