EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases
Figure 2
Gross
and microscopic findings from EBV-related SMN of liver. Liver specimen from
Patient 3 measured cm. Four nodules were found, ranging in size
from 0.4 cm to 6.7 cm (a). Histologic features on H&E staining included
moderate increased cellularity (with areas containing rounder, less fusiform
cells), lack of nuclear pleomorphism, and a low mitotic rate (1 mitotic
figure/50 high-powered field) (b). Nearly all cells were positive for
EBV-EBER by ISH, although intensity of the staining varied from cell to cell (c). Electron microscopy revealed spindle cells with abundant cytoplasmic
aggregates of actin microfilaments, including fusiform dense bodies and
attachment plaques, confirming the diagnosis of a well-differentiated smooth
muscle proliferation (d).
