EBV-Associated Smooth Muscle Neoplasms: Solid Tumors Arising in the Presence of Immunosuppression and Autoimmune Diseases

Table 1

Three different clinical scenarios in which EBV-related SMNs developed: patient summary. Dx = diagnosis. SMN = smooth muscle neoplasm. DOD = dead of disease. AWD = alive with disease. NED = no evidence of disease.

#	Age at Dx (year)	Cause of immune dysregulation	Date of start of immune dysregulation	Time to SMN	Site	Treatmen	Status follow-up
1	55M	Cadaveric renal transplant prednisone, cyclosporine, azathioprine, mycophenolate mofetil	1994	8 years	Liver (caudate 14 cm); lung	Observation (declined systemic therapy) (7/02)	DOD 5 months
2	18F	AIDS CD4 count = 8	Birth	11 years	Colon, chest, paraspinal/ vertebral, liver, gluteal, perigastric areas	Antiretrovirals doxorubicin, then dacarbazine (10/03)	AWD without progression, 5 years
3	25F	Psoriasis, etanercept therapy	20+ years, 8/04	20+ years, 5 months after etanercept started	Liver	Stopped immunosuppressives; hepatic resection (10/05)	NED, 3 years