Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma

Figure 1

Mediation of the proteasomal degradation pathway to antigen presentation by MHC class I. The immunoproteasomal degradation pathway is essential for antigen presentation by MHC class I. Defecive LMP2 expression results in tissue- and substrate-dependent abnormalities of immunoproteasomal functions. Therefore an impaired proteasome may promote the initial development of disease including tumorigenesis.