Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma
Figure 2
Histological findings of uterine leiomyosarcoma in LMP2-deficient mice. Histological findings of uterine LMS in LMP2-deficient mice ((a) to (c)). Among the histological findings of uterine LMS in LMP2-deficient mice, a cytoskeleton, which is characteristic of uterine LMS, is observed. ((b) and (c) magnification x400) Panel (e), in LMP2-deficient females, uterine LMS is observed at 6 months of age. The incidence at age 14 months is as high as 40% (e). The curve indicating the incidence of mouse uterine LMS is very similar to that indicating the incidence of human uterine LMS, which is observed after menopause. In mice with tumors of the uterus, significant weight loss is observed. Thus, a tumor that develops in the uterus is diagnosed as malignant, that is, uterine LMS.
