Sarcoma / 2011 / Article / Tab 5 / Review Article
Targeted Therapy of Ewing's Sarcoma Table 5 Biologic agents with potential synergy against Ewing’s sarcoma (EWS).
Drug Comments Reference Bisphosphonates Zoledronate, a potent inhibitor of EWS cell growth in vitro [51 ] Metformin Metformin inhibits both the mTORC1 pathwayand the IGF1R/IRS-1 pathway and at the same time downregulates the phosphorylation of Akt onserine 473 [52 , 53 ] Anti-angiogenic agents (bevacizumab) Preclinical studies: VEGF inhibition suppresses EWS growth. Three of five EWS patients had stable disease for >4 months in a phase I study of bevacizumab [54 , 55 ]
mTOR: mammalian target of rapamycin; IGF1R: insulin-like growth factor 1 receptor; IRS-1: insulin receptor substrates 1; VEGF: vascular endothelial growth factor.