Review Article
Targeted Therapy of Ewing's Sarcoma
Table 7
Anticipated future trials of targeted therapy for refractory and/or recurrent Ewing’s sarcoma (EWS).
| Sponsor site | Drugs | Rationale | Comments | PI contact info |
| Merck/UTMDACC | MK-0646+ MK8669 | IGF1R+/− mTOR | “up front” Rx; Phase II in development | Joseph Ludwig, MD [email protected] UTMDACC |
| Georgetown/UTMDACC | YK-4-279 | EWS-FLI1: RNA helicase inhibitor | Currently preclinical; clinical at UTMDACC | Jeffery Toretsky, MD [email protected] Pete Anderson MD, PhD [email protected] Aung Naing, MD [email protected] |
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