Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

Table 3

Validated direct EWS-FLI1 target genes.

EWS-FLI1 activated genes	Consequences of target suppression
Id2 [107]	Not known
GLI1 [108]	Reduced anchorage independent growth [109]
VEGF [110]	Decreased osteolysis [111]
STYXL1 [112]	Not known
PLD2 [113]	Inhibition of PDGF BB signalling
PTPL1 [114]	Reduced growth and increased chemosensitivity [114]
CAV1 [115]	Reduced anchorage independent growth, reduced tumorigenicity
GSTM4 [116]	Abrogation of oncogenic transformation, increased chemosensitivity [116]
NR0B1 [117, 118]	Abrogation of oncogenic transformation [119]
EZH2 [120]	Reduced anchorage independent growth, reduced tumorigenicity [120]
AURKA, AURKB [121]	Not known
Tenascin C [122]	Not known
EWS-FLI1 repressed genes	Consequences of target restoration
TGFBR2 [123]	Loss of tumorigenicity [123]
CDKN1A [124]	Inhibition of cell growth [124]
IGFBP3 [125]	Inhibition of cell growth and motility [126]
FOXO1 [127]	Not known
DKK1 [128, 129]	Decreased tumorigenicity [128]