Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor

Figure 4

𝛼-ALCAM-targeted PLNs bind specifically to osteosarcoma cell lines.  𝛼-ALCAM cys-diabody conjugated PLNs show specific binding (red) to two osteosarcoma cell lines expressing ALCAM, KHOS240s and MNNG-HOS. There was no binding to a cell line that does not express ALCAM, MiaPaCa. Fluorescence microscopy of PLNs is shown in red and DAPI nuclear counterstaining in blue (magnification 20x).