Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor

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</svg>-ALCAM-conjugated PLNs are internalized via receptor-mediated endocytosis.  <svg height="7.1750002" id="M20" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>-ALCAM-targeted PLNs incubated with the osteosarcoma cell line KHOS240s at 4 degrees and at 37 degrees Celsius show inhibition of receptor-mediated endocytosis at 4°C and rapid internalization of targeted PLNs at 37°C versus untargeted PLNs that do not bind under either circumstance. Fluorescence microscopy of PLNs (shown in red) with DAPI (blue) nuclear counterstaining (magnification 20x).</table>

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Figure 6

Figure 6: Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor 