Table 1: Relative cytotoxic potency of doxorubicin-loaded vehicles: ratio of (IC50)−1 between vehicles summarized by geometric mean (95% confidence interval) a .

Osteosarcoma cell lineUntargeted HPLNsTargeted HPLNsTargeted HPLNsFree Dox
overoveroverover
conventional liposomesuntargeted HPLNsconventional liposomestargeted HPLNs

KHOS240s5.4 (3.7–8.0)2.3 (1.5–3.3)12.2 (8.3–18.0)3.1 (2.1–4.6)
HOS7.0 (4.8–10.1)1.7 (1.1–2.4)11.6 (8.0–16.8)3.1 (2.1–4.5)
MNNG-HOS11.4 (5.4–23.9)2.0 (0.95–4.2)22.8 (10.8–47.8)3.6 (1.7–7.5)

Summary of all 3 lines b , c 5.9 c (4.6–7.6)2.0 (1.6–2.5)11.8 c (9.2–15.2)3.2 (2.6–4.1)

a Tukey HSD 95% confidence intervals for multiple comparisons in each cell line.
b Based on linear mixed effects model for log IC50 as a function of cell line and vehicle.
c Indicated potency ratio is 2.0-fold greater (95% CI: 1.4–2.8) in MNNG-HOS cell line, consistent with significant cell line by vehicle interaction (P = 0.015).