Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy

<table>Targets of SS18-SSX1/2 fusion oncoproteins involved in cell growth and proliferation, TP53 pathway, chromatin remodeling, and cytoskeleton remodeling, which may contribute to synovial sarcoma tumorigenesis. COM1-candidate of metastasis protein 1; PcG-polycomb group proteins; EGR-early growth response protein 1; mSIN3A-transcriptional regulator; HDAC-histone deacetylase complex; hBRM/hSNF2<i>α</i>-chromatin remodeling complex; TP53-tumor protein p53; HDM2-Mdm2 p53 binding protein homolog (mouse); XRCC4-X-ray repair complementing defective repair in Chinese hamster cells 4; IGF2-insulin-like growth factor 2; IGF-1R-insulin-like growth factor 1 receptor; BCL-2-B-cell CLL/lymphoma 2. *Only COM1 and mSIN3A have been described to interact directly with SS18-SSX1/2 fusion proteins.</table>

Sarcoma

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Figure 2: Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy 