Downstream and Intermediate Interactions of Synovial Sarcoma-Associated Fusion Oncoproteins and Their Implication for Targeted Therapy

Table 1

Interactors of SSX proteins.

Gene symbol	Gene description	Function	Reference
	SSX1
FUBP3	Far upstream element (FUSE) binding protein 3	Regulation of transcription	[151]
BMI1	BMI1 polycomb ring finger oncogene	PcG protein-transcriptional repressor	[61]
RING1A	Ring finger protein 1	PcG protein-transcriptional repressor	[61]
LHX4	LIM homeobox 4	Transcription factor	[152]
	SSX2
BMI1	BMI1 polycomb ring finger oncogene	PcG protein-transcriptional repressor	[61]
RING1A	Ring finger protein 1	PcG protein-transcriptional repressor	[61]
RING1B (RNF2)	Ring finger protein 2	PcG protein-transcriptional repressor	[117]
RAB3IP	RAB3A interacting protein (rabin3)	Protein transport	[63, 153]
SSX2IP	Synovial sarcoma, X breakpoint 2 interacting protein	Cell adhesion	[63, 153]
	SSX3
DDIT3 (CHOP)	DNA-damage-inducible transcript 3	Transcription factor	[151]
ZBTB25	Zinc finger and BTB domain containing 25	Regulation of transcription	[151]
ZBTB3	Zinc finger and BTB domain containing 3	Regulation of transcription	[151]
PCBD2	Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	Regulation of transcription	[151]
ZNF496	Zinc finger protein 496	Regulation of transcription	[151]
ZSCAN1	Zinc finger and SCAN domain containing 1	Regulation of transcription	[151]
SSX2IP	Synovial sarcoma, X breakpoint 2 interacting protein	Cell adhesion	[63, 153]
	SSX4
HIF1A	Hypoxia inducible factor 1, alpha subunit	Transcription factor	[151, 153]
PAX9	Paired box 9	Transcription factor	[151]
XBP1	X-box binding protein 1	Transcription factor	[151]
LZTR1	Leucine-zipper-like transcription regulator 1	Transcription factor	[151]
	SSX5
NFE2	Nuclear factor (erythroid-derived 2), 45 kDa	Regulation of transcription	[151]
PCBD2	Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	Regulation of transcription	[151]
ZSCAN1	Zinc finger and SCAN domain containing 1	Regulation of transcription	[151]