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Sarcoma
Volume 2012 (2012), Article ID 345161, 6 pages
http://dx.doi.org/10.1155/2012/345161
Clinical Study

Metastatic Patterns of Myxoid/Round Cell Liposarcoma: A Review of a 25-Year Experience

1Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
2Department of Orthopaedic Oncology, Tochigi Cancer Center, 4-9-13 Younann, Utsunomiya-shi, Tochigi 320-0834, Japan
3Department of Orthopaedic Surgery, Kyosai Tachikawa Hospital, 4-2-22 Nishikicho, Tachikawa-shi, Tokyo 190-8531, Japan
4Department of Orthopaedic Surgery, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-shi, Chiba 272-8513, Japan
5Department of Diagnostic Pathology, Keio University School of Medicine, Tokyo 160-8582, Japan

Received 20 October 2011; Revised 4 January 2012; Accepted 19 January 2012

Academic Editor: C. Fisher

Copyright © 2012 Naofumi Asano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myxoid/round cell liposarcoma (MRCL), unlike other soft tissue sarcomas, has been associated with unusual pattern of metastasis to extrapulmonary sites. In an attempt to elucidate the clinical features of MRCL with metastatic lesions, 58 cases, from the medical database of Keio University Hospital were used for the evaluation. 47 patients (81%) had no metastases, whereas 11 patients (11%) had metastases during their clinical course. Among the 11 patients with metastatic lesions, 8 patients (73%) had extrapulmonary metastases and 3 patients (27%) had pulmonary metastases. Patients were further divided into three groups; without metastasis, with extrapulmonary metastasis, and with pulmonary metastasis. When the metastatic patterns were stratified according to tumor size, there was statistical significance between the three groups ( 𝑃 = 0 . 0 2 8 ). The 8 cases with extrapulmonary metastases were all larger than 10 cm. Similarly, histological grading had a significant impact on metastatic patterns ( 𝑃 = 0 . 0 2 7 ). 3 cases with pulmonary metastatic lesions were all diagnosed as high grade. In conclusion, large size and low histological grade were significantly associated with extrapulmonary metastasis.