|
MicroRNAs | Functions in OS | Expression level in OS samples | Analyzed OS samples | MicroRNA targets in OS | References |
|
miR-34 family (miR-34a, 34b and 34c) | P53-related G1 arrest and apoptosis | Decreased | Cell lines and 107 tumor samples | CDK6, E2F3, Cyclin E2, BCL2 |
[30] |
miR-31 | P53-related cell proliferation | N/D | Cell lines | E2F2 |
[32] |
miR-192, miR-215 | P53-related cell cycle arrest | N/D | Cell lines | CDKN1A/p21 |
[31] |
miR140 | Chemoresistance to MTX and 5-FU | Increased in OS with chemoresistance | Mouse xenografts | HDAC4 |
[56] |
miR-215 | Chemoresistance to MTX | N/D | Cell line | DTL |
[57] |
miR-92a, miR-99b, miR-193a-5p, miR-422a | Discriminate good responders from poor ones | Increased | Cell lines and 27 paraffin-embedded samples | N/D |
[59] |
miR-132 | | Decreased | | | |
miR-21 | Cell invasion and migration | Increased | Cell lines and 8 tumor samples | RECK |
[41] |
miR-199a-3p | Cell proliferation and migration | Decreased | Cell lines and 12 tumor samples | MET, mTOR, STAT3, MCL-1, BCL-X |
[43] |
miR-143 | Pulmonary metastasis | Decreased in OS with metastasis | Cell lines and 22 tumor samples | MMP-13 |
[46] |
|