Occurrence of Comorbidities before and after Soft Tissue Sarcoma Diagnosis
Table 4
Risk factors for developing cardiovascular disease, anemia, and depression after soft tissue sarcoma diagnosis.
Characteristics
Cardiovascular disease
Anemia
Depression
HR multivariate #
95% CI
HR multivariate #
95% CI
HR multivariate #
95% CI
Gender
Male
1.9
(1.1–3.5)
1.4
(0.7–2.8)
1.0
(0.4–2.4)
Female
1
reference
1
reference
1
reference
Age in years
<50
1
reference
1
reference
1
reference
50–<70
0.9
(0.4–1.8)
0.7
(0.3–1.8)
1.1
(0.6–2.4)
≥70
1.2
(0.5–2.5)
0.9
(0.3–2.4)
1.5
(0.7–3.5)
Location
Extremities
1
reference
Head and neck
0.8
(0.3–2.0)
Thorax
1.4
(0.6–3.1)
Abdomen or (retro)peritoneum
2.1
(1.1–4.6)
Overlapping sites and NOS
1.9
(0.8–4.7)
Treatment1
Surgery
0.6
(0.2–2.3)
0.7
(0.2–2.6)
Chemotherapy
1.7
(0.7–4.4)
1.9
(1.1–4.1)
NOS: not otherwise specified; HR: hazard ratio; 95% CI: 95% confidence interval; # the multivariate model included all factors that were univariately associated with the outcome; 1defined during the first six months after soft tissue sarcoma diagnosis.
