Embryonic Signaling Pathways and Rhabdomyosarcoma: Contributions to Cancer Development and Opportunities for Therapeutic Targeting

Figure 1

Overview of the Notch pathway. The pathway is active when a Notch ligand, such as Delta or Jagged, binds to a Notch receptor on a neighboring cell. Notch is cleaved and the cytoplasmic portion (ICN) translocates to the nucleus where it binds RBP-J in cooperation with Mastermind (MAML) to activate transcription of target genes.