Embryonic Signaling Pathways and Rhabdomyosarcoma: Contributions to Cancer Development and Opportunities for Therapeutic Targeting

<table>Overview of the canonical Wnt pathway. In the inactive state, Wnt is absent and <i>β</i>-catenin is phosphorylated by the destruction complex, leading to its degradation. In the active state, Wnt binds Frizzled (Fzd) and LRP. Dishevelled (Dsh) and axin are recruited to the Wnt-Fzd-LRP complex, which inhibits the destruction complex. <i>β</i>-catenin is no longer phosphorylated and can translocate to the nucleus to activate transcription of target genes.</table>

Sarcoma

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Figure 2

Figure 2: Embryonic Signaling Pathways and Rhabdomyosarcoma: Contributions to Cancer Development and Opportunities for Therapeutic Targeting 