Embryonic Signaling Pathways and Rhabdomyosarcoma: Contributions to Cancer Development and Opportunities for Therapeutic Targeting

Table 1

Embryonic signaling pathways in rhabdomyosarcoma.

Embryonic pathway	Mechanism	Reference
Notch	(i) Promotes proliferation, suppresses differentiation, and avoids irreversible cell cycle arrest	[18]
	(ii) Promotes invasiveness and mobility	[19]
	(iii) Promotes proliferation and suppresses differentiation	[20]
WNT	(i) Suppresses differentiation and resists apoptosis	[21]
	(ii) Promotes proliferation and resists apoptosis	[22]
Hedgehog	(i) Promotes proliferation	[23]
	(ii) Suppresses differentiation	[24]