Low Prevalence of TP53 Mutations and MDM2 Amplifications in Pediatric Rhabdomyosarcoma

Table 3

Mean age of first tumor onset according to MDM2 SNP309 or p53 codon 72 genotype.

	Allele (frequency)	Genotype	Number of patients (%)	Mean age ± STDEV (years)
MDM2 SNP309	T (60%)	T/T	16 (40)	6.4 ± 5.2
		T/G	16 (40)	6.7 ± 5.4
	G (40%)	G/G	8 (20)	7.6 ± 3.7
		T/G + G/G	24 (60)	7.0 ± 4.8
P53 codon 72 SNP	Arg (75%)	Arg/Arg	24 (60)	6.3 ± 5.2
		Arg/Pro	12 (30)	7.5 ± 4.8
	Pro (25%)	Pro/Pro	4 (10)	7.0 ± 4.8
		Arg/Arg + Arg/Pro	36 (90)	6.7 ± 5.0