Table 1: Genes hypermethylated in EWS primary tumors.

SymbolGene name5-AZA upregulated?Downregulated in EWS primary tumors?

ACVR1CActivin a receptor, type icNo*
AXLAxl receptor tyrosine kinaseYesYes
CALCACalcitonin/calcitonin-related polypeptide, alphaYesNo
CCNA1Cyclin a1YesNS
CD9Cd9 antigen (p24)YesNo
COL1A1 Collagen, type 1, alpha 1YesYes
CYP1B1Cytochrome p450, family 1, subfamily b, polypeptide 1YesYes
DDB2Damage-specific DNA-binding protein 2NoNo
E2F5EF transcription factor 5, p130 bindingNoNo
ELK3ETS-domain protein (SRF accessory protein 2)YesNo
EPHA3Eph receptor a3YesNo
ESR1Estrogen receptor 1NoNo
FZD9Frizzled homolog 9YesNo
HIF1AHypoxia inducible factor 1, alpha subunitNoYes
HOXB13Homeobox b13NoNo
HS3ST2Heparan sulfate 3-O-sulfotransferase 2YesNS
HTR1B5-hydroxytryptamine receptor 1BNoNS
ITGA6Integrin, alpha 6NoYes
LYNV-yes-1 Yamaguchi sarcoma viral related oncogene homologYesYes
MAP3K1Mitogen-activated protein kinase 1Yes*
MMEMembrane metalloendopeptidase NoYes
MMP2Matrix metallopeptidase 2 NoYes
NGFRNerve growth factor receptor YesNo
NTRK2Neurotrophic tyrosine kinase, receptor, type 2NoNo
RARRES1Retinoic acid receptor responder 1 YesNo
RYKRyk receptor-like tyrosine kinaseNoYes
SEPT5Septin 5NoNo
SERPINE1Serpin peptidase inhibitor, clade e, member 1
(nexin, PAI1)
YesYes
SMARCB1Swi/snf-related, matrix-associated, actin-dependent
regulator of chromatin, subfamily b
NoNo
SOX17Sry (sex determining region y)-box 17YesNo
TFAP2CTranscription factor AP gammaYesNS
TGFBITransforming growth factor, beta-induced, 68 kdaNoYes
TNK1Tyrosine kinase, nonreceptor, 1NoNS
UBA52Ubiquitin A-52 residue ribosomal protein fusion product 1YesNo
VCAN Chondroitin sulfate proteoglycan core protein 2 (versican)YesYes
WNT5AWingless-type MMTV integration site family, member 5ANoNo

*: Gene Expression Data unknown.
NS: Not statistically significant.