Molecular Alterations Associated with Osteosarcoma Development

Figure 1

The main steps of the tumor metastatic process. Tumor cells proliferate at the primary site and neovascularization is induced by tumor environment such as hypoxia. In turn, they migrate and invade into the bloodstream. These tumor cells in the circulation need to survive against anoikis to arrest in a distant organ. Metastatic colonization at the secondary site involves the interactions between tumor cells and the microenvironment.