Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma

Table 3

Tumor expression GLUT-1, HIF-1α, HIF-2α, and CAIX and their prognostic relevance for disease-specific survival in 206 patients with non-gastrointestinal soft tissue (univariate analyses; log-rank test, multivariate analyses; Cox proportional hazards model).

Characteristics	Univariate analyses					Multivariate analyses*
	Patients (𝑛)	Patients (%)	Median survival (months)	5-year survival (%)	𝑃	HR	95% CI	𝑃
GLUT-1					<0.001
Low expression	110	53	NR	64		1.000
High expression	83	40	28	42		1.697	1.083–2.659	0.021
Missing	13	6
HIF-1α					0.658
Low expression	77	37	91	54
High expression	123	60	80	54
Missing	6	3
HIF-2α					0.032
Low expression	66	32	NR	62		1.000
High expression	135	66	59	49		0.965	0.581–1.603	0.892
Missing	5	2
CAIX					0.067
Low expression	44	21	NR	65
High expression	162	79	58	50

NR: not reached.
*Only significant variables from the univariate analyses were entered into the multivariate analyses.