Table 1: Distribution of prognostic factors over three decades.

Prognostic factor ( )
1979–19831984–20022003–2008

Metastases at diagnosis24.1% (7)25.4% (15) 16.7% (7)0.58
Tumor in axial skeleton6.9% (2)8.5% (5)4.8% (2)0.51
Good histologic response24.1% (7)23.7% (14)35.7% (15)0.55
>15% reduction due to toxicity24.1% (7)20.3% (12)7.1% (3)0.04