Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Figure 1

Hierarchical clustering of all tumours based on the top-210 significant genes differentially expressed between metastases and primary tumours, identified by SAM analysis. Samples coloured in red, metastases; lilac, primary samples from patients who later developed metastases; green, primary samples from patients who did not develop metastases blue, clinical information on metastases not available. Gene cluster coloured in blue, CXCL1, -2, -3, IL6, and LOC131873; green, EGR1, -2, FOSB, FOS, and JUNB; red, surfactant genes. Red, increased gene expression; green, decreased gene expression. The cluster was made using average linkage and Pearson’s correlation.