Efficacy of Phosphatidylinositol-3 Kinase Inhibitors in a Primary Mouse Model of Undifferentiated Pleomorphic Sarcoma

Table 5

Toxicity of BEZ235 and BKM120 scored by percent loss in body weight.

	Number of mice with maximal loss in body weight
	5–10%	>10%	# >15%	Total
Doxorubicin alone	0/8 (0%)	0/8 (0%)	0	0/8 (0%)
BEZ235+Dox	2/10 (20%)	5/10 (50%)	2	7/10 (70%)
BKM120 alone	3/10 (30%)	2/10 (20%)	0	5/10 (50%)
BKM120+Dox	2/9 (22%)	1/9 (11%)	1	3/9 (33%)