Sarcoma

Review Article

A Meta-Analysis of Osteosarcoma Outcomes in the Modern Medical Era

Table 1

Osteosarcoma outcome studies spanning more than two decades (OS: overall survival, DFS: disease free survival).


Category	Journal	Lead author	Pub year	Focus	Source dates		DFS 3 yrs	DFS 5 yrs	DFS 10 yrs	OS 5 yrs	OS 7 yrs	OS 10 yrs	Recurr-ence	Limb salvage

General	Human Path	Gaffney	2006	General	1900–1966	465				18.0%
	Cal Med	Higinbotham	1965	General	1925–1955	130				18.5%		16.2%
	CORR	Johnson	1971	General	1928–1966	50				10.0%			14.0%	36.0%
	Cancer	Ohno	1971	General	1930–1960	41				17.1%
	Can J Surg	Huebert	1979	General	1930–1977	95				16.0%
	Can J Surg	Huebert	1979	General	1930–1977	95				16.0%
	JBJS Br	Foster	2007	General	1933–1959	31				21.0%				20.0%
	Acta Chir Scand	Poppe	1968	General	1938–1964	102				18.0%
	J Surg Oncol	Shrikhande	1977	General	1941–1970	139				15.1%
	J Surg Oncol	Rao	1977	General	1941–1970	139				15.1%
	CORR	Weiss	1978	General	1944–1975	50				10.0%
	JBJS Am	Price	1975	General	1946–1972	125		12.0%
	Cancer	Jaffe	1972	General	1950–1972	78				17.0%
	JBJS Am	Bleyer	1982	General	1952–1973	19				41.0%
	CORR	Brostrom	1982	General	1952–1974	57	19.0%
	Eur J Surg Oncol	Pylkkanen	1997	General	1958–1987	29			46.7%
	Acta Orthop Belg	Meskens	1993	General	1962–1987	51					41.0%
	CORR	Tunn	2004	General	1970–1997	78						70.0%
	Eur J Cancer	Bacci	2005	General	1972–1999	114 8		57.0%	52.0%	66.0%		57.0%
	Ped Perinat Epid	Parkes	2010	General	Pre 1978	NS						12.0%
	Ped Perinat Epid	Parkes	2010	General	Post 1977	NS						45.0%
	Cancer	Kager L	2010	General	1979–2004	27		48.0%		51.0%			40.7%
	Acta Chir Scand	Poppe	1968	General	1938–1964	102				18.0%

Age	Cancer	Mirabello	2009	All Ages	1973–2004	348 2				37.0%		32.0%
				0–24		185 5				62.0%
				25–59		974				58.0%
				60+		653				24.0%
	Pediatr Blood Cancer	Abate	2010	0–5	1972–1999	20		60.0%
				6–40		110 6		53.8%	52.1%
	Pediatr Blood Cancer	Worch	2010	0 – 5	1973–2006	38				51.9%
				6–19		126 8				67.3%
	J Cancer Res Clin Oncol	Harting	2010	0–10	1980–2000	7				50.0%		46.5%
				10–21.		235				54.0%		46.0%
				21–40		110				68.5%		55.0%
				40+		56				40.0%		37.0%
	J Chin Med Assoc	Hsieh	2009	Preadolescent	1980–2006	11				60.6%
				Adolescent		39				66.7%
	J Clin Oncol	Longhi	2008	65+	1961–2006	29				45.0%
	Ann Surg Oncol	Okada	2004	50+	1972–2002	55				58.6%
	J Pediatr Hematol Oncol	Bacci	2005	0–12	1972–1999	317		60.0%		67.0%
				13–40		819		58.0%		65.0%
	CORR	Carsi	2002	40+	1977–1998	47		32.5%

Treatment	Eur J Can	Bruer	1978	Lung Irradiation	1950–1973	106				9.0%
	Arch Orthop Trauma Surg	Kawai	1996	With Chemotherapy	1965–1993	32					47.0%
				Without Chemotherapy		9					38.0%
	Cancer	Gupta	2009	Proximal humerus, deltoid-sparing resection	1978–2005	23				77.0%
	J Surg Oncol	Kim	2009	Inadvertant curettage w/o treatment delay	1985–2005	20		90.0%		89.4%
				Control Group		40		76.8%		83.9%
	Radiology	Phillips	1969	Preop Radiation	1945–1965	23				26.0%
				Surgery Only		11				9.0%
	Int J Radiat Oncol Biol Phys	DeLaney	2005	Resection	1980–2002	36		51.9%		73.9%			32.3%
				No Surgery		5		25.0%		25.0%			60.0%

Tumor feature	Pediatric Blood Cancer	Yaclin	2008	C-erb-2+	1976–2007	24		22.4%		32.3%
				C-erb-2−		32		50.0%		62.1%
	Clin Transl Oncol	Gonzalez-Bilalabeitia	2009	COSS	1977–2003	170 2			48.9%			58.9%
				High LDH		14				43.0%
				Normal LDH		52				65.0%
	Pediatr Blood Cancer	Franke	2011	Local recurrence	1980–2003	38		27.0%		34.0%
	Pediatr Blood Cancer	Lee	2009	Low Risk	1985–2006	98		81.6%	81.6%	93.8%		93.8%
				Intermediate Risk		128		59.0%	57.8%	76.5%		74.6%
				HighRisk		62		34.0%	31.6%	47.0%		36.5%
	Eur J Cancer	Grimer	2005	Local Recurrence	1976–2001	57				41.0%

Location	Canc Treat Res	Bielack	2009	Extremity	1980–2005	246 4				75.0%		70.0%
	JBJS Br	Grimer	1999	Pelvis	1971–1996	36			18.0%
	Spine J	Schoenfeld	2010	Spine	1982–2008	26				31.0%
	Jpn J Clin Oncol	Lee	2010	Flat Bone	1985–2006	17		39.6%		51.5%
				Extremity		424		61.4%		72.9%
	Eur J Cancer Care	Shenoy	2008	Humerus	1950–1975	18			35.0%
				All Sites		112 6		55.0%		66.0%
	CORR	Schneidrbauer	2007	Fibula	1919–2000	36				53.0%		41.0%
	Ann Surg Oncol	Daecke	2005	Hand and Forearm	1977–2000	33		65.4%		86.2%
	Ned Tijdschr Geneeskd	Ham	2000	Pelvis	1957–1995	62				15.0%
	Oncology	Matsuo	2005	Pelvis	NS	50				29.5%

Metastatic	J Clin Oncol	Longhi	2008	Age >65 yrs	1961–2006	14				0.0%
Metastatic	Ann Surg Oncol	Okada	2004	Age >50 yrs	1972–2002	7				25.0%