Sarcoma / 2012 / Article / Tab 1 / Review Article
Assessment of Minimal Residual Disease in Ewing Sarcoma Table 1 Summary of Key Studies Using RT-PCR for MRD Detection in Ewing Sarcoma.
Author [Reference] N (pts) Key Findings Peter [9 ] 36 31% had MRD in either blood or marrow at diagnosis at diagnosis Pfeiderer [13 ] 16 38% had MRD in BM, while only 6% had CTC at diagnosis West [12 ] 28 25% of newly diagnosed localized pts had MRD in blood or marrow, compared to 50% with relapsed/metastatic disease Fagnou [11 ] 67 26% of patients had MRD in blood at diagnosis, but this was not correlated with clinical features or outcome.33% of patients had BM MRD, with worse outcome De Alava [6 ] 28 MRD in blood and/or marrow developed prior to clinical progression Zoubek [14 ] 35 7/23 (30%) had BM MRD at diagnosis, but this did not predict relapse Thomson [3 ] 9 Survival was correlated with speed of clearance of MRD in blood and BM Sumerauer [10 ] 22 MRD in marrow found in 31% of localized and 50% of metastatic pts Merino [15 ] 12 Quantitative RT-PCR can be used to measure efficacy of stem cell purging methods Schleiermacher [2 ] 172 MRD in blood or BM at diagnosis is associated with worse survival in patients with otherwise localized disease Avigad [5 ] 26 43% of pts had marrow MRD at diagnosisMRD developed prior to clinical recurrence in 10 of 11 patients Yaniv [16 ] 11 Tumor cells frequently contaminate stem cell harvests, and are associated with relapse after transplantation.Relapse is preceded by MRD in BM and/or blood
MRD, minimal residual disease; BM, bone marrow.